Multifocal avascular osteonecrosis despite appropriate anticoagulation therapy in a patient with systemic lupus erythematosus and antiphospholipid syndrome

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[Systemic lupus erythematosus and antiphospholipid syndrome].

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by the synthesis of antinuclear antibodies. Nucleosomes-the disc-like-structural unit of chromatin being composed of histones and DNA-are the primary antigenic structure that induces the formation of complement-activating antigen-antibody complexes in basement membranes. The autoreactivity in SLE has been elucidat...

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ژورنال

عنوان ژورنال: BMJ Case Reports

سال: 2018

ISSN: 1757-790X

DOI: 10.1136/bcr-2018-225532